Immobilized copper nanoparticles on biodegradable magnetic starch composite: investigation of its ovarian cancer, cytotoxicity, and antioxidant effects

Abstract

In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Cu NPs fabricated potato starch functionalized magnetic nanomaterial (Fe3O4@starch/Cu nanocomposite). The prepared nanocomposite were characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping and ICP-OES. The biogenic synthesized Fe3O4@starch/Cu nanocomposite was explored in the anti-ovarian cancer investigations against ovarian cancer cell lines (PA-1, Caov-3, SW 626, and SK-OV-3). The material exhibited significant cytotoxicities against the ovarian cancer cell lines. However, it was considerably inactive against the normal HUVEC cell line. The antioxidant potential of Fe3O4@starch/Cu nanocomposite was also investigated by DPPH method. The Fe3O4@starch/Cu nanocomposite revealed the significant antioxidant potentials according to the IC50 value.

Keywords

• Fe3O4@starch/Cu nanocomposite
• Ovarian cancer
• Cytotoxicity