Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

• Brian M. Barth,
• Weiyuan Wang,
• Paul T. Toran,
• Todd E. Fox,
• Charyguly Annageldiyev,
• Regina M. Ondrasik,
• Nicole R. Keasey,
• Timothy J. Brown,
• Viola G. Devine,
• Emily C. Sullivan,
• Andrea L. Cote,
• Vasiliki Papakotsi,
• Su-Fern Tan,
• Sriram S. Shanmugavelandy,
• Tye G. Deering,
• David B. Needle,
• Stephan T. Stern,
• Junjia Zhu,
• Jason Liao,
• Aaron D. Viny,
• David J. Feith,
• Ross L. Levine,
• Hong-Gang Wang,
• Thomas P. Loughran, Jr,
• Arati Sharma,
• Mark Kester,
• David F. Claxton

Affiliations

Brian M. Barth

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; Brian M. Barth, Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, 46 College Rd, Durham, NH 03824

Weiyuan Wang

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

Paul T. Toran

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

Todd E. Fox

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA

Charyguly Annageldiyev

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA

Regina M. Ondrasik

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA

Nicole R. Keasey

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA

Timothy J. Brown

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX

Viola G. Devine

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA

Emily C. Sullivan

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

Andrea L. Cote

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

Vasiliki Papakotsi

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

Su-Fern Tan

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA; University of Virginia Cancer Center, Charlottesville, VA

Sriram S. Shanmugavelandy

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA

Tye G. Deering

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA

David B. Needle

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH

Stephan T. Stern

Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute–Frederick National Laboratory for Cancer Research, Frederick, MD

Junjia Zhu

Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA

Jason Liao

Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA

Aaron D. Viny

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

David J. Feith

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA; University of Virginia Cancer Center, Charlottesville, VA

Ross L. Levine

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Hong-Gang Wang

Penn State Hershey Cancer Institute, Hershey, PA; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA; Pediatric Molecular Oncology Program, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA

Thomas P. Loughran, Jr

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA; University of Virginia Cancer Center, Charlottesville, VA

Arati Sharma

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA

Mark Kester

Penn State Hershey Cancer Institute, Hershey, PA; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA; University of Virginia Cancer Center, Charlottesville, VA; nanoSTAR Institute, University of Virginia, Charlottesville, VA

David F. Claxton

Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA; Penn State Hershey Cancer Institute, Hershey, PA; David F. Claxton, Penn State Hershey Cancer Institute, Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033