Microcirculation in arterial hypertension patients receiving beta-adrenoblockers

Abstract

Aim. To compare microcirculation (MC) functional status during the treatment with beta-adrenoblockers (BAB), with and without vasodilatatory effects, in patients with Stage I-II arterial hypertension (AH). Material and methods. In total, 61 Stage I-II patients and 30 relatively healthy volunteers were examined. AH patients received nebivolol or metoprolol for 24 weeks. At baseline, and after 4, 12, and 24 weeks, MC hemodynamic types (MCHT) were assessed by laser Doppler flowmetry (LAKK-02 device, “LASMA”, Russia). Ключевые слова: артериальная гипертония, состояние микроциркуляции, гемодинамические типы микроциркуляции, β-адреноблокаторы, небиволол, метопролол. Results. AH is characterized by heterogeneous MC changes: hyperemic MCHT is typical for Stage I AH, and stasis-congestive or spastic MCHT – for Stage II AH. During metoprolol therapy, normocirculatory MCHT increased, and hyperemic MCHT decreased. Nebivolol demonstrated normalizing effects, manifesting in decreased hyperemic or spastic MCHT and increased normocirculatory MCHT. Conclusion. Metoprolol improved MC functional status. Nebivolol normalized functional and morphological MC status.

Keywords

• arterial hypertension
• microcirculation status
• microcirculation hemodynamic types
• beta-adrenoblockers
• nebivolol
• metaprolol