Frontiers in Pharmacology (Jan 2021)
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival
- Baolong Li,
- Baolong Li,
- Baolong Li,
- Zhengtai Chen,
- Zhengtai Chen,
- Zhengtai Chen,
- Xiaobin Luo,
- Xiaobin Luo,
- Xiaobin Luo,
- Chenxi Zhang,
- Chenxi Zhang,
- Chenxi Zhang,
- Hongyu Chen,
- Hongyu Chen,
- Hongyu Chen,
- Shuxuan Wang,
- Mengyao Zhao,
- Mengyao Zhao,
- Mengyao Zhao,
- Haiwei Ma,
- Haiwei Ma,
- Haiwei Ma,
- Junling Liu,
- Junling Liu,
- Junling Liu,
- Mengshi Cheng,
- Mengshi Cheng,
- Yanyan Yang,
- Yanyan Yang,
- Hede Yan,
- Hede Yan
Affiliations
- Baolong Li
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Baolong Li
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Baolong Li
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Zhengtai Chen
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Zhengtai Chen
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Zhengtai Chen
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Xiaobin Luo
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Xiaobin Luo
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Xiaobin Luo
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Chenxi Zhang
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Chenxi Zhang
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Chenxi Zhang
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Hongyu Chen
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Hongyu Chen
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Hongyu Chen
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Shuxuan Wang
- Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mengyao Zhao
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Mengyao Zhao
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Mengyao Zhao
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Haiwei Ma
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Haiwei Ma
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Haiwei Ma
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Junling Liu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Junling Liu
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- Junling Liu
- The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
- Mengshi Cheng
- Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- Mengshi Cheng
- The First Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Yanyan Yang
- Infectious Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- Yanyan Yang
- The First Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Hede Yan
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Hede Yan
- Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
- DOI
- https://doi.org/10.3389/fphar.2020.612932
- Journal volume & issue
-
Vol. 11
Abstract
Multiterritory perforator flap is an important plastic surgery technique, yet its efficacy can be limited by partial necrosis at the choke Ⅱ zone. Butylphthalide (NBP) has been used for many diseases but has not been studied in the multiterritory perforator flap. With the effect of NBP, we observed increasing in capillary density, inhibition of autophagy and oxidative stress, and a reduction in apoptosis of cells, all consistent with increased flap survival. However, the protective effect of NBP on multiterritory perforator flap was lost following administration of the autophagy agonist rapamycin (Rap). Through the above results, we assumed that NBP promotes flap survival by inhibiting autophagy. Thus, this study has found a new pharmacological effect of NBP on the multiterritory perforator by inhibiting autophagy to prevent distal postoperative necrosis and exert effects on angiogenesis, oxidative stress, and apoptosis within the flap.
Keywords
