Enantioselective synthesis of planar chiral ferrocenes via palladium-catalyzed annulation with diarylethynes

Abstract

When Boc-L-Val-OH was used as a ligand for the enantioselective Pd(II)-catalyzed annulation of N,N-substituted aminomethyl ferrocene derivatives with diarylethynes, ferrocenes with planar chirality could be achieved with excellent enantioselectivity (up to 99% ee).

Keywords

• annulation
• asymmetric catalysis
• C–H activation
• ferrocene
• palladium
• planar chirality