Nature Communications (Jul 2017)

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

  • M. Carola Zillikens,
  • Serkalem Demissie,
  • Yi-Hsiang Hsu,
  • Laura M. Yerges-Armstrong,
  • Wen-Chi Chou,
  • Lisette Stolk,
  • Gregory Livshits,
  • Linda Broer,
  • Toby Johnson,
  • Daniel L. Koller,
  • Zoltán Kutalik,
  • Jian’an Luan,
  • Ida Malkin,
  • Janina S. Ried,
  • Albert V. Smith,
  • Gudmar Thorleifsson,
  • Liesbeth Vandenput,
  • Jing Hua Zhao,
  • Weihua Zhang,
  • Ali Aghdassi,
  • Kristina Åkesson,
  • Najaf Amin,
  • Leslie J. Baier,
  • Inês Barroso,
  • David A. Bennett,
  • Lars Bertram,
  • Rainer Biffar,
  • Murielle Bochud,
  • Michael Boehnke,
  • Ingrid B. Borecki,
  • Aron S. Buchman,
  • Liisa Byberg,
  • Harry Campbell,
  • Natalia Campos Obanda,
  • Jane A. Cauley,
  • Peggy M. Cawthon,
  • Henna Cederberg,
  • Zhao Chen,
  • Nam H. Cho,
  • Hyung Jin Choi,
  • Melina Claussnitzer,
  • Francis Collins,
  • Steven R. Cummings,
  • Philip L. De Jager,
  • Ilja Demuth,
  • Rosalie A. M. Dhonukshe-Rutten,
  • Luda Diatchenko,
  • Gudny Eiriksdottir,
  • Anke W. Enneman,
  • Mike Erdos,
  • Johan G. Eriksson,
  • Joel Eriksson,
  • Karol Estrada,
  • Daniel S. Evans,
  • Mary F. Feitosa,
  • Mao Fu,
  • Melissa Garcia,
  • Christian Gieger,
  • Thomas Girke,
  • Nicole L. Glazer,
  • Harald Grallert,
  • Jagvir Grewal,
  • Bok-Ghee Han,
  • Robert L. Hanson,
  • Caroline Hayward,
  • Albert Hofman,
  • Eric P. Hoffman,
  • Georg Homuth,
  • Wen-Chi Hsueh,
  • Monica J. Hubal,
  • Alan Hubbard,
  • Kim M. Huffman,
  • Lise B. Husted,
  • Thomas Illig,
  • Erik Ingelsson,
  • Till Ittermann,
  • John-Olov Jansson,
  • Joanne M. Jordan,
  • Antti Jula,
  • Magnus Karlsson,
  • Kay-Tee Khaw,
  • Tuomas O. Kilpeläinen,
  • Norman Klopp,
  • Jacqueline S. L. Kloth,
  • Heikki A. Koistinen,
  • William E. Kraus,
  • Stephen Kritchevsky,
  • Teemu Kuulasmaa,
  • Johanna Kuusisto,
  • Markku Laakso,
  • Jari Lahti,
  • Thomas Lang,
  • Bente L. Langdahl,
  • Lenore J. Launer,
  • Jong-Young Lee,
  • Markus M. Lerch,
  • Joshua R. Lewis,
  • Lars Lind,
  • Cecilia Lindgren,
  • Yongmei Liu,
  • Tian Liu,
  • Youfang Liu,
  • Östen Ljunggren,
  • Mattias Lorentzon,
  • Robert N. Luben,
  • William Maixner,
  • Fiona E. McGuigan,
  • Carolina Medina-Gomez,
  • Thomas Meitinger,
  • Håkan Melhus,
  • Dan Mellström,
  • Simon Melov,
  • Karl Michaëlsson,
  • Braxton D. Mitchell,
  • Andrew P. Morris,
  • Leif Mosekilde,
  • Anne Newman,
  • Carrie M. Nielson,
  • Jeffrey R. O’Connell,
  • Ben A. Oostra,
  • Eric S. Orwoll,
  • Aarno Palotie,
  • Stephen C. J. Parker,
  • Munro Peacock,
  • Markus Perola,
  • Annette Peters,
  • Ozren Polasek,
  • Richard L. Prince,
  • Katri Räikkönen,
  • Stuart H. Ralston,
  • Samuli Ripatti,
  • John A. Robbins,
  • Jerome I. Rotter,
  • Igor Rudan,
  • Veikko Salomaa,
  • Suzanne Satterfield,
  • Eric E. Schadt,
  • Sabine Schipf,
  • Laura Scott,
  • Joban Sehmi,
  • Jian Shen,
  • Chan Soo Shin,
  • Gunnar Sigurdsson,
  • Shad Smith,
  • Nicole Soranzo,
  • Alena Stančáková,
  • Elisabeth Steinhagen-Thiessen,
  • Elizabeth A. Streeten,
  • Unnur Styrkarsdottir,
  • Karin M. A. Swart,
  • Sian-Tsung Tan,
  • Mark A. Tarnopolsky,
  • Patricia Thompson,
  • Cynthia A. Thomson,
  • Unnur Thorsteinsdottir,
  • Emmi Tikkanen,
  • Gregory J. Tranah,
  • Jaakko Tuomilehto,
  • Natasja M. van Schoor,
  • Arjun Verma,
  • Peter Vollenweider,
  • Henry Völzke,
  • Jean Wactawski-Wende,
  • Mark Walker,
  • Michael N. Weedon,
  • Ryan Welch,
  • H.-Erich Wichmann,
  • Elisabeth Widen,
  • Frances M. K. Williams,
  • James F. Wilson,
  • Nicole C. Wright,
  • Weijia Xie,
  • Lei Yu,
  • Yanhua Zhou,
  • John C. Chambers,
  • Angela Döring,
  • Cornelia M. van Duijn,
  • Michael J. Econs,
  • Vilmundur Gudnason,
  • Jaspal S. Kooner,
  • Bruce M. Psaty,
  • Timothy D. Spector,
  • Kari Stefansson,
  • Fernando Rivadeneira,
  • André G. Uitterlinden,
  • Nicholas J. Wareham,
  • Vicky Ossowski,
  • Dawn Waterworth,
  • Ruth J. F. Loos,
  • David Karasik,
  • Tamara B. Harris,
  • Claes Ohlsson,
  • Douglas P. Kiel

DOI
https://doi.org/10.1038/s41467-017-00031-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.