ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway

Xin Wen; Xin Wen; Si Chen; Si Chen; Xueting Chen; Hui Qiu; Wei Wang; Nie Zhang; Wanming Liu; Tingting Wang; Xin Ding; Longzhen Zhang; Longzhen Zhang; Longzhen Zhang

doi:10.3389/fonc.2022.887068

Frontiers in Oncology (Sep 2022)

ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway

Xin Wen,
Xin Wen,
Si Chen,
Si Chen,
Xueting Chen,
Hui Qiu,
Wei Wang,
Nie Zhang,
Wanming Liu,
Tingting Wang,
Xin Ding,
Longzhen Zhang,
Longzhen Zhang,
Longzhen Zhang

Affiliations

Xin Wen: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Xin Wen: Cancer Institute of Xuzhou Medical University, Xuzhou, China
Si Chen: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Si Chen: Department of Radiation Oncology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Xueting Chen: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Hui Qiu: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Wei Wang: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Nie Zhang: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Wanming Liu: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Tingting Wang: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Xin Ding: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Longzhen Zhang: Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Longzhen Zhang: Cancer Institute of Xuzhou Medical University, Xuzhou, China
Longzhen Zhang: Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou, China

DOI: https://doi.org/10.3389/fonc.2022.887068
Journal volume & issue: Vol. 12

Abstract

Read online

Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expression of ITGB5 in PAAD and its role in promoting invasiveness and transitivity in PAAD. Besides, the knockdown of ITGB5 increased cell sensitivity to radiation by promoting DNA damage repair and the MEK/ERK signaling pathway. Collectively, these results show that ITGB5 plays an essential role in pancreatic cancer growth and survival.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords