Structural and functional alterations in MRI-negative drug-resistant epilepsy and associated gene expression features
Ting Liu,
Sheng Wang,
Yingjie Tang,
Sisi Jiang,
Huixia Lin,
Fei Li,
Dezhong Yao,
Xian Zhu,
Cheng Luo,
Qifu Li
Affiliations
Ting Liu
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, PR China
Sheng Wang
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, PR China
Yingjie Tang
MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 610054, PR China
Sisi Jiang
MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 610054, PR China
Huixia Lin
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, PR China
Fei Li
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, PR China
Dezhong Yao
MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 610054, PR China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu 2019RU035, PR China
Xian Zhu
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, PR China; Correspondence authors at: Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China.
Cheng Luo
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 610054, PR China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu 2019RU035, PR China; Correspondence authors at: Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China.
Qifu Li
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, PR China; Correspondence authors at: Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Hainan Province, PR China.
Neuroimaging techniques have been widely used in the study of epilepsy. However, structural and functional changes in the MRI-negative drug-resistant epilepsy (DRE) and the genetic mechanisms behind the structural alterations remain poorly understood. Using structural and functional MRI, we analyzed gray matter volume (GMV) and regional homogeneity (ReHo) in DRE, drug-sensitive epilepsy (DSE) and healthy controls. Gene expression data from Allen human brain atlas and GMV/ReHo were evaluated to obtain drug resistance-related and epilepsy-associated gene expression and compared with real transcriptional data in blood. We found structural and functional alterations in the cerebellum of DRE patients, which may be related to the mechanisms of drug resistance in DRE. Our study confirms that changes in brain morphology and regional activity in DRE patients may be associated with abnormal gene expression related to nervous system development. And SP1, as an important transcription factor, plays an important role in the mechanism of drug resistance.
