Prevalence of the <i>Puumala orthohantavirus</i> Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia
Yuriy Davidyuk,
Anton Shamsutdinov,
Emmanuel Kabwe,
Ruzilya Ismagilova,
Ekaterina Martynova,
Alexander Belyaev,
Eduard Shuralev,
Vladimir Trifonov,
Tatiana Savitskaya,
Guzel Isaeva,
Svetlana Khaiboullina,
Albert Rizvanov,
Sergey Morzunov
Affiliations
Yuriy Davidyuk
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Anton Shamsutdinov
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Emmanuel Kabwe
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Ruzilya Ismagilova
OpenLab “Omics Technology”, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia
Ekaterina Martynova
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Alexander Belyaev
Department of Zoology and General Biology, Zoological Museum, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia
Eduard Shuralev
Department of Applied Ecology, Institute of Environmental Sciences, Kazan Federal University, Kazan 420097, Russia
Vladimir Trifonov
Kazan Research Institute of Epidemiology and Microbiology, Kazan 420012, Russia
Tatiana Savitskaya
Kazan Research Institute of Epidemiology and Microbiology, Kazan 420012, Russia
Guzel Isaeva
Kazan Research Institute of Epidemiology and Microbiology, Kazan 420012, Russia
Svetlana Khaiboullina
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Albert Rizvanov
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Sergey Morzunov
OpenLab “Gene and Cell Technologies”, Kazan Federal University, Institute of Fundamental Medicine and Biology, Kazan 420008, Russia
Puumala orthohantavirus (PUUV) causes nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) commonly diagnosed in Europe. The majority of HFRS cases in the European part of Russia are diagnosed in the Volga Federal District, which includes the Republic of Tatarstan (RT). The current study aims to analyze the genetic variability of PUUV in Pre-Kama region of the RT bounded by the Volga, Kama, and Vyatka rivers. In 2017, bank voles were caught in seven isolated forest traps in the Pre-Kama region and for the 26 PUUV-positive samples, the partial small (S), medium (M), and large (L) genome segment sequences were obtained and analyzed. It was determined that all identified PUUV strains belong to the Russian (RUS) genetic lineage; however, the genetic distance between strains is not directly correlated with the geographical distance between bank vole populations. One of the identified strains has S and L segments produced from one parental strain, while the M segment was supplied by another, suggesting that this strain could be the reassortant. We suggest that the revealed pattern of the PUUV strains distribution could be the result of a series of successive multidirectional migratory flows of the bank voles to the Pre-Kama region in the postglacial period.
