Antibiotics
(May 2020)
Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection
James B. Doub,
Vincent Y. Ng,
Aaron J. Johnson,
Magdalena Slomka,
Joseph Fackler,
Bri’Anna Horne,
Michael J. Brownstein,
Matthew Henry,
Francisco Malagon,
Biswajit Biswas
Affiliations
James B. Doub
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Vincent Y. Ng
Department of Orthopedic surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Aaron J. Johnson
Department of Orthopedic surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Magdalena Slomka
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Joseph Fackler
Adaptive Phage Therapeutics, Gaithersburg, MD 20878, USA
Bri’Anna Horne
Adaptive Phage Therapeutics, Gaithersburg, MD 20878, USA
Michael J. Brownstein
Adaptive Phage Therapeutics, Gaithersburg, MD 20878, USA
Matthew Henry
Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA
Francisco Malagon
Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA
Biswajit Biswas
Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD 21702, USA
DOI
https://doi.org/10.3390/antibiotics9050241
Journal volume & issue
Vol. 9,
no. 5
Abstract
Read online
This is a case of a 72 year old male with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous dose of bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage of bacteriophage therapy. Nevertheless, treatment was successful and the patient’s severe chronic infection was eradicated.
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