Scientific Reports (Nov 2021)

Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study

  • Richard Rezar,
  • Vera Paar,
  • Clemens Seelmaier,
  • Ingrid Pretsch,
  • Philipp Schwaiger,
  • Kristen Kopp,
  • Reinhard Kaufmann,
  • Thomas K. Felder,
  • Erika Prinz,
  • Geza Gemes,
  • Rudin Pistulli,
  • Uta C. Hoppe,
  • Bernhard Wernly,
  • Michael Lichtenauer

DOI
https://doi.org/10.1038/s41598-021-01389-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Abstract Prognostication after cardiopulmonary resuscitation (CPR) is complex. Novel biomarkers like soluble suppression of tumorigenicity 2 (sST2) may provide an objective approach. A total of 106 post-CPR patients were included in this single-center observational prospective study. Serum sST2 levels were obtained 24 h after admission. Individuals were assigned to two groups: patients below and above the overall cohort’s median sST2 concentration. Primary outcome was a combined endpoint at 6 months (death or Cerebral Performance Category > 2); secondary endpoint 30-day mortality. A uni- and multivariate logistic regression analysis were conducted. Elevated sST2-levels were associated with an increased risk for the primary outcome (OR 1.011, 95% CI 1.004–1.019, p = 0.004), yet no patients with poor neurological outcome were observed at 6 months. The optimal empirical cut-off for sST2 was 46.15 ng/ml (sensitivity 81%, specificity 53%, AUC 0.69). Levels above the median (> 53.42 ng/ml) were associated with higher odds for both endpoints (death or CPC > 2 after 6 months: 21% vs. 49%, OR 3.59, 95% CI 1.53–8.45, p = 0.003; death after 30 days: 17% vs. 43.3%, OR 3.75, 95% CI 1.52–9.21, p = 0.003). A positive correlation of serum sST2 after CPR with mortality at 30 days and 6 months after cardiac arrest could be demonstrated.