ALK Positive Anaplastic Large Cell Lymphoma Presenting as Extensive Bone Involvement

Abstract

Anaplastic lymphoma kinase (ALK) positive Anaplastic large cell lymphoma (ALCL) represents approximately 2% of all Non-Hodgkin’s lymphomas that commonly involves nodal as well as a wide variety of extra nodal sites, as skin, soft tissue, bones and lungs, although primary or secondary involvement of bone is rare. Herein, we report a case of 14-year-old female child presented as extensive bony involvement with a clinical diagnosis of bone tumour/ small round cell tumour, which was proved to be ALK positive ALCL on histopathological examination.

Keywords

• anaplastic large cell lymphoma
• anaplastic lymphoma kinase
• cd30
• multifocal osseous involvement