Nature Communications (Feb 2021)
Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains
- Fabien Aubry,
- Sofie Jacobs,
- Maïlis Darmuzey,
- Sebastian Lequime,
- Leen Delang,
- Albin Fontaine,
- Natapong Jupatanakul,
- Elliott F. Miot,
- Stéphanie Dabo,
- Caroline Manet,
- Xavier Montagutelli,
- Artem Baidaliuk,
- Fabiana Gámbaro,
- Etienne Simon-Lorière,
- Maxime Gilsoul,
- Claudia M. Romero-Vivas,
- Van-Mai Cao-Lormeau,
- Richard G. Jarman,
- Cheikh T. Diagne,
- Oumar Faye,
- Ousmane Faye,
- Amadou A. Sall,
- Johan Neyts,
- Laurent Nguyen,
- Suzanne J. F. Kaptein,
- Louis Lambrechts
Affiliations
- Fabien Aubry
- Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS
- Sofie Jacobs
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy
- Maïlis Darmuzey
- GIGA-Stem Cells/GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), C.H.U. Sart Tilman, University of Liège
- Sebastian Lequime
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology
- Leen Delang
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy
- Albin Fontaine
- Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées (IRBA)
- Natapong Jupatanakul
- Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS
- Elliott F. Miot
- Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS
- Stéphanie Dabo
- Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS
- Caroline Manet
- Mouse Genetics Laboratory, Institut Pasteur
- Xavier Montagutelli
- Mouse Genetics Laboratory, Institut Pasteur
- Artem Baidaliuk
- Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS
- Fabiana Gámbaro
- Evolutionary Genomics of RNA Viruses Group, Institut Pasteur
- Etienne Simon-Lorière
- Evolutionary Genomics of RNA Viruses Group, Institut Pasteur
- Maxime Gilsoul
- GIGA-Stem Cells/GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), C.H.U. Sart Tilman, University of Liège
- Claudia M. Romero-Vivas
- Laboratorio de Enfermedades Tropicales, Departamento de Medicina, Fundación Universidad del Norte
- Van-Mai Cao-Lormeau
- Institut Louis Malardé
- Richard G. Jarman
- Viral Diseases Branch, Walter Reed Army Institute of Research
- Cheikh T. Diagne
- Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar
- Oumar Faye
- Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar
- Ousmane Faye
- Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar
- Amadou A. Sall
- Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar
- Johan Neyts
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy
- Laurent Nguyen
- GIGA-Stem Cells/GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), C.H.U. Sart Tilman, University of Liège
- Suzanne J. F. Kaptein
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy
- Louis Lambrechts
- Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS
- DOI
- https://doi.org/10.1038/s41467-021-21199-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Here, the authors compare seven low passage Zika virus (ZIKV) strains representing the recently circulating viral genetic diversity of African and Asian strains and find that African ZIKV strains have higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice.
