Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case

Paulo Victor Mendes Penafort; Lady Paola Aristizabal Arboleda; Sérgio Takashi Kussaba; Izilda Aparecida Cardinalli; Regina Maria Holanda de Mendonça; Márcio Ajudarte Lopes; Pablo Agustin Vargas; Alan Roger Santos-Silva

Oral Oncology Reports (Mar 2024)

Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case

Paulo Victor Mendes Penafort,
Lady Paola Aristizabal Arboleda,
Sérgio Takashi Kussaba,
Izilda Aparecida Cardinalli,
Regina Maria Holanda de Mendonça,
Márcio Ajudarte Lopes,
Pablo Agustin Vargas,
Alan Roger Santos-Silva

Affiliations

Paulo Victor Mendes Penafort: Corresponding author. Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Av. Limeira, 901, 13.414-903, Piracicaba, São Paulo (SP), Brazil.; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Brazil
Lady Paola Aristizabal Arboleda: Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Brazil
Sérgio Takashi Kussaba: Cathedral College, Boa Vista, RR, Brazil
Izilda Aparecida Cardinalli: Boldrini Children's Hospital, Campinas, SP, Brazil
Regina Maria Holanda de Mendonça: Boldrini Children's Hospital, Campinas, SP, Brazil
Márcio Ajudarte Lopes: Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Brazil
Pablo Agustin Vargas: Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Brazil
Alan Roger Santos-Silva: Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Brazil

Journal volume & issue: Vol. 9
p. 100193

Abstract

Read online

B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a type of malignancy involving uncontrolled proliferation of B-precursor lymphoid cells. This case report delineates B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) manifesting in the mandible and medullary regions of a 10-year-old female. Clinically, an irregular swelling with bone cortical destruction and weight loss was observed. Histopathological examination revealed proliferation of CD10, CD43, CD79a, PAX-5, TDT, CD99, and FLI-1 positive small round blue cells, with a 49% lymphoblast infiltration in the bone marrow. Chemotherapy was administered, leading to disease control during the 5-year follow-up.

Published in Oral Oncology Reports

ISSN: 2772-9060 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.sciencedirect.com/journal/oral-oncology-reports

About the journal