Increased apoptosis of peripheral blood mononuclear cells in patients 
with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis

Janina Grzegorczyk; Marek L. Kowalski; Anna Pilat; Jolanta Iwaszkiewicz

doi:10.1080/09629350290000087

Mediators of Inflammation (Jan 2002)

Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis

Janina Grzegorczyk,
Marek L. Kowalski,
Anna Pilat,
Jolanta Iwaszkiewicz

Affiliations

Janina Grzegorczyk: Department of Clinical Immunology and Allergy, Faculty of Medicine, Medical University of Lodz, 251 Pomorska St., Lodz 92-213, Poland
Marek L. Kowalski: Department of Clinical Immunology and Allergy, Medical University of Lodz, Lodz, Poland
Anna Pilat: Department of Clinical Immunology and Allergy, Medical University of Lodz, Lodz, Poland
Jolanta Iwaszkiewicz: Department of Clinical Immunology and Allergy, Medical University of Lodz, Lodz, Poland

DOI: https://doi.org/10.1080/09629350290000087
Journal volume & issue: Vol. 11, no. 4
pp. 225 – 233

Abstract

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Background: The goal of our study was to examine spontaneous and stimulated apoptosis of peripheral blood MNC from allergic patients, sensitized to Der p I antigen as compared to cells from non-atopic subjects. Furthermore we aimed to investigate which populations of mononuclear cells (lymphocytes, monocytes) undergo the apoptosis and to determine relations between apoptosis and serum levels of sFas/APO-1, ICE/caspase-1 or TNF-α.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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