Macular sensitivity after half-dose verteporfin photodynamic therapy in central serous chorioretinopathy

Abstract

Thuss Sanguansak, Prapapan Pitujaturont, Yosanan Yospaiboon, Suthasinee Sinawat, Tanapat Ratanapakorn, Chavakij Bhoomibunchoo Department of Ophthalmology, Faculty of Medicine, KKU Eye Center, Khon Kaen University, Khon Kaen, Thailand Objective: To study the macular sensitivity after half-dose verteporfin photodynamic therapy in patients with resolved central serous chorioretinopathy using the automated static perimeter.Methods: Prospective consecutive case study of 24 patients with resolved central serous chorioretinopathy was performed. The macular sensitivity was measured using a conventional automated static perimeter with the Swedish interactive threshold algorithm 10-2 and foveal threshold. Best corrected visual acuity, intraocular pressure, fundus examination, macular thickness, and volume were also examined. The mean macular sensitivities of the affected eyes and their normal fellow eyes were calculated and compared. P<0.05 was considered statistically significant.Results: The mean macular sensitivities of the affected eyes were lower than the normal fellow eyes with a statistically significant difference in all areas of the study (P<0.05). Best corrected visual acuity improved significantly from pretreatment (0.26±0.3 logMAR) to posttreatment (0.075±0.15 logMAR, P<0.05). Macular thicknesses in affected eyes were 230.66±67.34 µm and in the normal eyes were 238.33±92.26 µm (P=0.68). Macular volumes in affected eyes were 8.77±0.49 and in the normal eyes were 8.70±0.50 (P=0.60). These findings were not statistically significant.Conclusion: Eyes with resolved central serous chorioretinopathy after half-dose verteporfin photodynamic therapy had lower macular sensitivity than normal fellow eyes. These findings agreed well with the previous microperimetric studies. The conventional automated static perimeter can also be used when a microperimeter is not available. Keywords: macular sensitivity, half-dose photodynamic therapy, automated static perimeter, central serous chorioretinopathy