Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Xuexiang Han; Yiye Li; Ying Xu; Xiao Zhao; Yinlong Zhang; Xiao Yang; Yongwei Wang; Ruifang Zhao; Gregory J. Anderson; Yuliang Zhao; Guangjun Nie

doi:10.1038/s41467-018-05906-x

Nature Communications (Aug 2018)

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Xuexiang Han,
Yiye Li,
Ying Xu,
Xiao Zhao,
Yinlong Zhang,
Xiao Yang,
Yongwei Wang,
Ruifang Zhao,
Gregory J. Anderson,
Yuliang Zhao,
Guangjun Nie

Affiliations

Xuexiang Han: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Yiye Li: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Ying Xu: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Xiao Zhao: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Yinlong Zhang: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Xiao Yang: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Yongwei Wang: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ruifang Zhao: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Gregory J. Anderson: QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital
Yuliang Zhao: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Guangjun Nie: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology

DOI: https://doi.org/10.1038/s41467-018-05906-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreatic cancer treatment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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