International Journal of General Medicine (Mar 2023)

N-Cadherin Expression with Metastasis of Neck Lymph Nodes in Patients with Nasopharyngeal Carcinoma

  • Yusuf M,
  • Pradana YPA,
  • Rahmawati R,
  • Farhat F,
  • Kusumastuti EH,
  • Ekoputro JW

Journal volume & issue
Vol. Volume 16
pp. 1029 – 1037

Abstract

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Muhtarum Yusuf,1,2 Yogi Putra Adhi Pradana,1,2 Rosydiah Rahmawati,1,2 Farhat Farhat,3 Etty Hary Kusumastuti,2,4 Jeffi Wahyu Ekoputro5 1Department of Otorhinolaryngology, Head, and Neck Surgery, Airlangga University, Surabaya, East Java, Indonesia; 2Department of Otorhinolaryngology, Head, and Neck Surgery, Dr. Soetomo General Teaching Hospital, Surabaya, East Java, Indonesia; 3Department of Otorhinolaryngology, Head, and Neck Surgery, Sumatera Utara University, Medan, North Sumatera, Indonesia; 4Department of Pathology Anatomy, Airlangga University, Surabaya, East Java, Indonesia; 5Muhammadiyah Surabaya University, Surabaya, East Java, 60113, IndonesiaCorrespondence: Muhtarum Yusuf, Department of Otorhinolaryngology, Head, and Neck Surgery, Airlangga University, Jl. Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, Jawa Timur, 60285, 60286, Indonesia, Tel +62 031 5501078, Email [email protected]: Lymph node (LN) metastases were one characteristic of negative progress of NPC patient despite its advanced therapeutic approaches. One mechanism for the occurrence of epithelial to mesenchymal transition (EMT)-mediated metastases is by increasing N-cadherin expression. The purpose of this research is to determine investigating N-cadherin expression against metastatic LN in NPC cases.Methods: Samples were taken by unproportionate stratified random sampling. N-cadherin expression was examined using immunohistochemistry methods. N-cadherin expression was assessed visually by binocular light microscopy. We analyzed these data using Mann–Whitney U-test to examine N-cadherin expression and lymph node metastases.Results: A strong expression was found in N3 group by 63.6%; 27.3% in the N2 group and 9.1% in the N1 group. In patients with NPC N0 or without lymph node metastases, N-cadherin expression is 0%. The expression of N-cadherin is indeed an indicator of the occurrence of lymph node metastases in NPC with a statistically significant analysis of p = 0.026 (p < 0.05).Conclusion: There were correlations between N-cadherin expression and lymph node metastasis on NPC patients.Keywords: N-cadherin, nasopharyngeal carcinoma, cancer, immunohistochemistry

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