Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery

Lauren K. Yum; Mariana X. Byndloss; Sanford H. Feldman; Hervé Agaisse

doi:10.1038/s41467-019-09808-4

Nature Communications (Apr 2019)

Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery

Lauren K. Yum,
Mariana X. Byndloss,
Sanford H. Feldman,
Hervé Agaisse

Affiliations

Lauren K. Yum: Department of Microbiology, Immunology, and Cancer Biology, University of Virginia
Mariana X. Byndloss: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
Sanford H. Feldman: Center for Comparative Medicine, University of Virginia
Hervé Agaisse: Department of Microbiology, Immunology, and Cancer Biology, University of Virginia

DOI: https://doi.org/10.1038/s41467-019-09808-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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The bacterial pathogen Shigella flexneri causes bacillary dysentery (bloody diarrhoea). Here, Yum et al. present an infant rabbit model of S. flexneri infection that recapitulates human disease symptoms and features bacterial dissemination as an essential determinant of pathogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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