Терапевтический архив (Dec 2019)

Heart - type fatty acid binding protein in prognosis of ischemic stroke at the hospital stage

  • O V Lyang,
  • A G Kochetov,
  • I A Zhirova,
  • Yu V Novozhenova,
  • O O Ivoylov,
  • L V Stakhovskaya

DOI
https://doi.org/10.26442/00403660.2019.12.000469
Journal volume & issue
Vol. 91, no. 12
pp. 35 – 40

Abstract

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Heart - type fatty acid binding protein (h-FABP), in addition to myocardium, is also contained in the brain cells. The blood concentration of h-FABP in cerebral ischemia can be a marker of ischemic stroke course. Aim. To investigate the importance of h-FABP in the prognosis of ischemic stroke (IS). Materials and methods. The study included 302 patients in the acute period of ischemic stroke. All patients were determined the concentration of h-FABP in the serum 1 day by enzyme immunoassay. SPSS and Microsoft Excel software were used for statistical data processing. Results. The most frequent adverse events at the hospital stage were lethal outcome (LO), thrombotic complications and pneumonia. Statistically significant differences in the level of h-FABP between the groups of presence and absence of LO were revealed both by confidence intervals of Central values and by statistical criteria. The ROC analysis values of h-FABP in the presence of the LO confirmed its predictive value, area under the curve amounted to 0.776±0.061 (0.655-0.896), p

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