Frontiers in Neurology (Jun 2020)

Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia

  • Xianyun Meng,
  • Xianyun Meng,
  • Jianjun Zheng,
  • Jianjun Zheng,
  • Yingpeng Liu,
  • Yingpeng Liu,
  • Yi Yin,
  • Kelei Hua,
  • Shishun Fu,
  • Yunfan Wu,
  • Guihua Jiang

DOI
https://doi.org/10.3389/fneur.2020.00609
Journal volume & issue
Vol. 11

Abstract

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The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI.

Keywords