Gasdermin-A3 pore formation propagates along variable pathways

Stefania A. Mari; Kristyna Pluhackova; Joka Pipercevic; Matthew Leipner; Sebastian Hiller; Andreas Engel; Daniel J. Müller

doi:10.1038/s41467-022-30232-8

Nature Communications (May 2022)

Gasdermin-A3 pore formation propagates along variable pathways

Stefania A. Mari,
Kristyna Pluhackova,
Joka Pipercevic,
Matthew Leipner,
Sebastian Hiller,
Andreas Engel,
Daniel J. Müller

Affiliations

Stefania A. Mari: Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich
Kristyna Pluhackova: Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich
Joka Pipercevic: Biozentrum, University of Basel
Matthew Leipner: Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich
Sebastian Hiller: Biozentrum, University of Basel
Andreas Engel: Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich
Daniel J. Müller: Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich

DOI: https://doi.org/10.1038/s41467-022-30232-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Gasdermin-A3 pore formation propagates along diverse pathways. It begins with membrane attachment and oligomeric pre-assembly. Once inserted in the membrane, the oligomers re-assemble into various shapes and sizes, which open their lytic pores.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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