Research progress of endoplasmic reticulum stress of hypoxic pulmonary hypertension

Abstract

Hypoxic pulmonary hypertension (HPH) is a serious complication caused by long-term hypoxia,which is characterized by persistent vasoconstriction and irreversible vascular remodeling. The hypoxia may destroy protein folding process in endoplasmic reticulum and activate endoplasmic reticulum stress(ERS). As the core response of cell stress, ERS is closely related to the development of HPH.

Keywords

• hypoxic pulmonary hypertension|endoplasmic reticulum stress|unfolded protein response