The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo

Briana Rackley; Chang-Soo Seong; Evan Kiely; Rebecca E. Parker; Manali Rupji; Bhakti Dwivedi; John M. Heddleston; William Giang; Neil Anthony; Teng-Leong Chew; Melissa Gilbert-Ross

doi:10.1038/s42003-021-01663-8

Communications Biology (Jan 2021)

The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo

Briana Rackley,
Chang-Soo Seong,
Evan Kiely,
Rebecca E. Parker,
Manali Rupji,
Bhakti Dwivedi,
John M. Heddleston,
William Giang,
Neil Anthony,
Teng-Leong Chew,
Melissa Gilbert-Ross

Affiliations

Briana Rackley: Department of Hematology and Medical Oncology, Emory University School of Medicine
Chang-Soo Seong: Department of Hematology and Medical Oncology, Emory University School of Medicine
Evan Kiely: Department of Hematology and Medical Oncology, Emory University School of Medicine
Rebecca E. Parker: Department of Hematology and Medical Oncology, Emory University School of Medicine
Manali Rupji: Biostatistics Shared Resource, Winship Cancer Institute of Emory University
Bhakti Dwivedi: Bioinformatics and Systems Biology Shared Resource, Winship Cancer Institute of Emory University
John M. Heddleston: Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute
William Giang: Integrated Cellular Imaging Core, Emory University School of Medicine, Emory University
Neil Anthony: Integrated Cellular Imaging Core, Emory University School of Medicine, Emory University
Teng-Leong Chew: Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute
Melissa Gilbert-Ross: Department of Hematology and Medical Oncology, Emory University School of Medicine

DOI: https://doi.org/10.1038/s42003-021-01663-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

Read online

Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to treat RAS-driven tumours.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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