Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
Juan Lu,
Qin Sun,
Zheng-Chao Tu,
Qing Lv,
Pi-Xian Shui,
Yong-Xian Cheng
Affiliations
Juan Lu
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China
Qin Sun
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China
Zheng-Chao Tu
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Road, Guangzhou 510530, China
Qing Lv
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China
Pi-Xian Shui
School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China
Yong-Xian Cheng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
