Nature Communications (Mar 2021)
Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma
- Stefan Antonowicz,
- Zsolt Bodai,
- Tom Wiggins,
- Sheraz R. Markar,
- Piers R. Boshier,
- Yan Mei Goh,
- Mina E. Adam,
- Haonan Lu,
- Hiromi Kudo,
- Francesca Rosini,
- Robert Goldin,
- Daniela Moralli,
- Catherine M. Green,
- Chris J. Peters,
- Nagy Habib,
- Hani Gabra,
- Rebecca C. Fitzgerald,
- Zoltan Takats,
- George B. Hanna
Affiliations
- Stefan Antonowicz
- Department of Surgery and Cancer, Imperial College London
- Zsolt Bodai
- Department of Metabolism, Digestion and Reproduction, Imperial College London
- Tom Wiggins
- Department of Surgery and Cancer, Imperial College London
- Sheraz R. Markar
- Department of Surgery and Cancer, Imperial College London
- Piers R. Boshier
- Department of Surgery and Cancer, Imperial College London
- Yan Mei Goh
- Department of Surgery and Cancer, Imperial College London
- Mina E. Adam
- Department of Surgery and Cancer, Imperial College London
- Haonan Lu
- Department of Surgery and Cancer, Imperial College London
- Hiromi Kudo
- Department of Surgery and Cancer, Imperial College London
- Francesca Rosini
- Centre for Pathology, Imperial College London
- Robert Goldin
- Centre for Pathology, Imperial College London
- Daniela Moralli
- Chromosome Dynamics Core, Wellcome Centre for Human Genetics, University of Oxford
- Catherine M. Green
- Chromosome Dynamics Core, Wellcome Centre for Human Genetics, University of Oxford
- Chris J. Peters
- Department of Surgery and Cancer, Imperial College London
- Nagy Habib
- Department of Surgery and Cancer, Imperial College London
- Hani Gabra
- Department of Surgery and Cancer, Imperial College London
- Rebecca C. Fitzgerald
- MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge
- Zoltan Takats
- Department of Metabolism, Digestion and Reproduction, Imperial College London
- George B. Hanna
- Department of Surgery and Cancer, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-021-21800-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.
