Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels

Abstract

The signalling pathways regulating how the mammary gland stroma interacts with the epithelia to then regulate gland development are unclear. Here, the authors identify Sfrp3 as regulating stroma communication via Wnts, on deletion, this increases ductal invasion and initiates an early pregnancy state.