Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

Zhen Chen; Caoqi Lei; Chao Wang; Nan Li; Mrinal Srivastava; Mengfan Tang; Huimin Zhang; Jong Min Choi; Sung Yun Jung; Jun Qin; Junjie Chen

doi:10.1038/s41467-018-08004-0

Nature Communications (Jan 2019)

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

Zhen Chen,
Caoqi Lei,
Chao Wang,
Nan Li,
Mrinal Srivastava,
Mengfan Tang,
Huimin Zhang,
Jong Min Choi,
Sung Yun Jung,
Jun Qin,
Junjie Chen

Affiliations

Zhen Chen: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Caoqi Lei: Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
Chao Wang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Nan Li: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Mrinal Srivastava: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Mengfan Tang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Huimin Zhang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Jong Min Choi: Department of Molecular and Cellular Biology, Baylor College of Medicine
Sung Yun Jung: Department of Molecular and Cellular Biology, Baylor College of Medicine
Jun Qin: Department of Molecular and Cellular Biology, Baylor College of Medicine
Junjie Chen: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-08004-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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AMPK is regulates cellular energy and has been extensively studied, although our knowledge of downstream substrates is incomplete. Here, Chen et al. perform global quantitative analysis for AMPK-dependent sites and validate one hit, ARMC10, as a direct AMPK effector of mitochondrial dynamics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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