Nature Communications (Jul 2020)
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
- Weang-Kee Ho,
- Min-Min Tan,
- Nasim Mavaddat,
- Mei-Chee Tai,
- Shivaani Mariapun,
- Jingmei Li,
- Peh-Joo Ho,
- Joe Dennis,
- Jonathan P. Tyrer,
- Manjeet K. Bolla,
- Kyriaki Michailidou,
- Qin Wang,
- Daehee Kang,
- Ji-Yeob Choi,
- Suniza Jamaris,
- Xiao-Ou Shu,
- Sook-Yee Yoon,
- Sue K. Park,
- Sung-Won Kim,
- Chen-Yang Shen,
- Jyh-Cherng Yu,
- Ern Yu Tan,
- Patrick Mun Yew Chan,
- Kenneth Muir,
- Artitaya Lophatananon,
- Anna H. Wu,
- Daniel O. Stram,
- Keitaro Matsuo,
- Hidemi Ito,
- Ching Wan Chan,
- Joanne Ngeow,
- Wei Sean Yong,
- Swee Ho Lim,
- Geok Hoon Lim,
- Ava Kwong,
- Tsun L. Chan,
- Su Ming Tan,
- Jaime Seah,
- Esther M. John,
- Allison W. Kurian,
- Woon-Puay Koh,
- Chiea Chuen Khor,
- Motoki Iwasaki,
- Taiki Yamaji,
- Kiak Mien Veronique Tan,
- Kiat Tee Benita Tan,
- John J. Spinelli,
- Kristan J. Aronson,
- Siti Norhidayu Hasan,
- Kartini Rahmat,
- Anushya Vijayananthan,
- Xueling Sim,
- Paul D. P. Pharoah,
- Wei Zheng,
- Alison M. Dunning,
- Jacques Simard,
- Rob Martinus van Dam,
- Cheng-Har Yip,
- Nur Aishah Mohd Taib,
- Mikael Hartman,
- Douglas F. Easton,
- Soo-Hwang Teo,
- Antonis C. Antoniou
Affiliations
- Weang-Kee Ho
- School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia
- Min-Min Tan
- School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia
- Nasim Mavaddat
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Mei-Chee Tai
- Cancer Research Malaysia
- Shivaani Mariapun
- School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia
- Jingmei Li
- Human Genetics, Genome Institute of Singapore
- Peh-Joo Ho
- Human Genetics, Genome Institute of Singapore
- Joe Dennis
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Jonathan P. Tyrer
- Strangeways Research Laboratory, University of Cambridge
- Manjeet K. Bolla
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Kyriaki Michailidou
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Qin Wang
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Daehee Kang
- Department of Preventive Medicine, Seoul National University College of Medicine
- Ji-Yeob Choi
- Department of Biomedical Sciences, Seoul National University Graduate School
- Suniza Jamaris
- Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Sook-Yee Yoon
- Cancer Research Malaysia
- Sue K. Park
- Department of Preventive Medicine, Seoul National University College of Medicine
- Sung-Won Kim
- Department of Surgery, Daerim Saint Mary’s Hospital
- Chen-Yang Shen
- Institute of Biomedical Sciences, Academia Sinica
- Jyh-Cherng Yu
- Department of Surgery, Tri-Service General Hospital
- Ern Yu Tan
- Department of General Surgery, Tan Tock Seng Hospital
- Patrick Mun Yew Chan
- Department of General Surgery, Tan Tock Seng Hospital
- Kenneth Muir
- Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, The University of Manchester
- Artitaya Lophatananon
- Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, The University of Manchester
- Anna H. Wu
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Daniel O. Stram
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Keitaro Matsuo
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Hidemi Ito
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Ching Wan Chan
- Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore
- Joanne Ngeow
- Division of Medical Oncology, National Cancer Centre Singapore
- Wei Sean Yong
- Division of Surgical Oncology, National Cancer Centre
- Swee Ho Lim
- Breast Department, KK Women’s and Children’s Hospital
- Geok Hoon Lim
- Breast Department, KK Women’s and Children’s Hospital
- Ava Kwong
- Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre
- Tsun L. Chan
- Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre
- Su Ming Tan
- General Surgery, Changi General Hospital
- Jaime Seah
- General Surgery, Changi General Hospital
- Esther M. John
- Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine
- Allison W. Kurian
- Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine
- Woon-Puay Koh
- Health Services and Systems Research, Duke-NUS Medical School, Stanford University School of Medicine
- Chiea Chuen Khor
- Human Genetics, Genome Institute of Singapore
- Motoki Iwasaki
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Taiki Yamaji
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Kiak Mien Veronique Tan
- Division of Surgical Oncology, National Cancer Centre
- Kiat Tee Benita Tan
- Division of Surgical Oncology, National Cancer Centre
- John J. Spinelli
- Population Oncology, BC Cancer, 675 West 10th Avenue
- Kristan J. Aronson
- Department of Public Health Sciences, and Cancer Research Institute, Queen’s University
- Siti Norhidayu Hasan
- Cancer Research Malaysia
- Kartini Rahmat
- Biomedical Imaging Department, Faculty of Medicine, University of Malaya
- Anushya Vijayananthan
- Biomedical Imaging Department, Faculty of Medicine, University of Malaya
- Xueling Sim
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Paul D. P. Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Alison M. Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Jacques Simard
- Genomics Center, CHU de Québec-Université Laval Research 2705 Blvd Laurier Québec (Québec) G1V 4G2
- Rob Martinus van Dam
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Cheng-Har Yip
- Sime Darby Medical Centre
- Nur Aishah Mohd Taib
- Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti
- Mikael Hartman
- Department of Surgery, National University Hospital and NUHS
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Soo-Hwang Teo
- Cancer Research Malaysia
- Antonis C. Antoniou
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-17680-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.
