Nature Communications (Jul 2020)

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

  • Weang-Kee Ho,
  • Min-Min Tan,
  • Nasim Mavaddat,
  • Mei-Chee Tai,
  • Shivaani Mariapun,
  • Jingmei Li,
  • Peh-Joo Ho,
  • Joe Dennis,
  • Jonathan P. Tyrer,
  • Manjeet K. Bolla,
  • Kyriaki Michailidou,
  • Qin Wang,
  • Daehee Kang,
  • Ji-Yeob Choi,
  • Suniza Jamaris,
  • Xiao-Ou Shu,
  • Sook-Yee Yoon,
  • Sue K. Park,
  • Sung-Won Kim,
  • Chen-Yang Shen,
  • Jyh-Cherng Yu,
  • Ern Yu Tan,
  • Patrick Mun Yew Chan,
  • Kenneth Muir,
  • Artitaya Lophatananon,
  • Anna H. Wu,
  • Daniel O. Stram,
  • Keitaro Matsuo,
  • Hidemi Ito,
  • Ching Wan Chan,
  • Joanne Ngeow,
  • Wei Sean Yong,
  • Swee Ho Lim,
  • Geok Hoon Lim,
  • Ava Kwong,
  • Tsun L. Chan,
  • Su Ming Tan,
  • Jaime Seah,
  • Esther M. John,
  • Allison W. Kurian,
  • Woon-Puay Koh,
  • Chiea Chuen Khor,
  • Motoki Iwasaki,
  • Taiki Yamaji,
  • Kiak Mien Veronique Tan,
  • Kiat Tee Benita Tan,
  • John J. Spinelli,
  • Kristan J. Aronson,
  • Siti Norhidayu Hasan,
  • Kartini Rahmat,
  • Anushya Vijayananthan,
  • Xueling Sim,
  • Paul D. P. Pharoah,
  • Wei Zheng,
  • Alison M. Dunning,
  • Jacques Simard,
  • Rob Martinus van Dam,
  • Cheng-Har Yip,
  • Nur Aishah Mohd Taib,
  • Mikael Hartman,
  • Douglas F. Easton,
  • Soo-Hwang Teo,
  • Antonis C. Antoniou

DOI
https://doi.org/10.1038/s41467-020-17680-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.