Nature Communications (Dec 2016)

Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma

  • Xiao-Yan Ming,
  • Li Fu,
  • Li-Yi Zhang,
  • Yan-Ru Qin,
  • Ting-Ting Cao,
  • Kwok Wah Chan,
  • Stephanie Ma,
  • Dan Xie,
  • Xin-Yuan Guan

DOI
https://doi.org/10.1038/ncomms13568
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling.