A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

Ailone Tichon; Noa Gil; Yoav Lubelsky; Tal Havkin Solomon; Doron Lemze; Shalev Itzkovitz; Noam Stern-Ginossar; Igor Ulitsky

doi:10.1038/ncomms12209

Nature Communications (Jul 2016)

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

Ailone Tichon,
Noa Gil,
Yoav Lubelsky,
Tal Havkin Solomon,
Doron Lemze,
Shalev Itzkovitz,
Noam Stern-Ginossar,
Igor Ulitsky

Affiliations

Ailone Tichon: Department of Biological Regulation, Weizmann Institute of Science
Noa Gil: Department of Biological Regulation, Weizmann Institute of Science
Yoav Lubelsky: Department of Biological Regulation, Weizmann Institute of Science
Tal Havkin Solomon: Department of Molecular Genetics, Weizmann Institute of Science
Doron Lemze: Department of Molecular Cell Biology,Weizmann Institute of Science
Shalev Itzkovitz: Department of Molecular Cell Biology,Weizmann Institute of Science
Noam Stern-Ginossar: Department of Molecular Genetics, Weizmann Institute of Science
Igor Ulitsky: Department of Biological Regulation, Weizmann Institute of Science

DOI: https://doi.org/10.1038/ncomms12209
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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