The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Albert Sufianov; Aferin Beilerli; Sema Begliarzade; Tatiana Ilyasova; Valentin Kudriashov; Yanchao Liang; Ozal Beylerli

Non-coding RNA Research (Mar 2023)

The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Albert Sufianov,
Aferin Beilerli,
Sema Begliarzade,
Tatiana Ilyasova,
Valentin Kudriashov,
Yanchao Liang,
Ozal Beylerli

Affiliations

Albert Sufianov: Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Aferin Beilerli: Department of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, Russia
Sema Begliarzade: Republican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, Russia
Tatiana Ilyasova: Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia
Valentin Kudriashov: Gastric Cancer Center, West China Hospital of Sichuan University, China
Yanchao Liang: Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China
Ozal Beylerli: Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Corresponding author. Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russia.

Journal volume & issue: Vol. 8, no. 1
pp. 89 – 95

Abstract

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Human periodontal ligament-derived cells are important seed cells for periodontal regeneration, and their osteogenic potential closely affects alveolar bone repair and periodontal regeneration. Human periodontal ligament stem cells are pluripotent stem cells of mesenchymal origin, which can differentiate in osteoblasts and cementoblasts. However, the molecular mechanism of this differentiation activity is poorly studied. Noncoding RNAs (ncRNAs) belong to RNAs, which do not encode proteins and represent a large segment of the human transcriptome, mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). It was shown that ncRNAs is involved in the proliferation and differentiation of cells, epigenetic modifications, apoptosis, as well as in complex control and pathogenesis of various diseases. NcRNAs are actively involved in the regulation of osteogenic genes in human periodontal ligament-derived cells. This article reviews the research progress of ncRNAs in the regulatory targets, pathways and functions of ncRNAs in the osteogenic differentiation of human periodontal ligament-derived cells.

Published in Non-coding RNA Research

ISSN: 2468-0540 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/non-coding-rna-research/

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