The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

Job van Riet; Harmen J. G. van de Werken; Edwin Cuppen; Ferry A. L. M. Eskens; Margot Tesselaar; Linde M. van Veenendaal; Heinz-Josef Klümpen; Marcus W. Dercksen; Gerlof D. Valk; Martijn P. Lolkema; Stefan Sleijfer; Bianca Mostert

doi:10.1038/s41467-021-24812-3

Nature Communications (Jul 2021)

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

Job van Riet,
Harmen J. G. van de Werken,
Edwin Cuppen,
Ferry A. L. M. Eskens,
Margot Tesselaar,
Linde M. van Veenendaal,
Heinz-Josef Klümpen,
Marcus W. Dercksen,
Gerlof D. Valk,
Martijn P. Lolkema,
Stefan Sleijfer,
Bianca Mostert

Affiliations

Job van Riet: Cancer Computational Biology Center, Erasmus MC Cancer Institute, University Medical Center
Harmen J. G. van de Werken: Cancer Computational Biology Center, Erasmus MC Cancer Institute, University Medical Center
Edwin Cuppen: Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht
Ferry A. L. M. Eskens: Department of Medical Oncology, Erasmus MC Cancer Institute
Margot Tesselaar: Department of Medical Oncology, Cancer Institute, University of Amsterdam
Linde M. van Veenendaal: Department of Medical Oncology, Cancer Institute, University of Amsterdam
Heinz-Josef Klümpen: Department of Medical Oncology, Amsterdam University Medical Centers, Cancer Center Amsterdam
Marcus W. Dercksen: Department of Internal Medicine, Maxima Medisch Centrum
Gerlof D. Valk: Department of Endocrine Oncology, University Medical Center Utrecht
Martijn P. Lolkema: Department of Medical Oncology, Erasmus MC Cancer Institute
Stefan Sleijfer: Department of Medical Oncology, Erasmus MC Cancer Institute
Bianca Mostert: Department of Medical Oncology, Erasmus MC Cancer Institute

DOI: https://doi.org/10.1038/s41467-021-24812-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulations, tumour mutational burden patterns, drivers and actionable somatic alterations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal