B‐cell maturation antigen‐based therapies post‐talquetamab in relapsed or refractory multiple myeloma

Abstract

Abstract Talquetamab recently received approval for relapsed refractory multiple myeloma. However, there is currently no available data on how patients perform with BCMA based agents after progression on talquetamab. Herein, we present the outcome of 10 patients who received BCMA based therapies following talquetamab. The median follow‐up was 9.5 months (range: 6–24 months). The median progression free survival was 5.5 months (range: 1–10 months). Patients had varying grades of cytokine release syndrome and Immune effector cell‐associated neurotoxicity syndrome. Our results suggest that treatment with talquetamab followed by BCMA based therapies is feasible and can be considered as clinically indicated.

Keywords

• BCMA
• bispecific antibodies
• CAR‐T therapy
• GPRC5D
• multiple myeloma
• sequencing