Nature Communications (Jun 2021)
Dynamics of replication origin over-activation
- Haiqing Fu,
- Christophe E. Redon,
- Bhushan L. Thakur,
- Koichi Utani,
- Robin Sebastian,
- Sang-Min Jang,
- Jacob M. Gross,
- Sara Mosavarpour,
- Anna B. Marks,
- Sophie Z. Zhuang,
- Sarah B. Lazar,
- Mishal Rao,
- Shira T. Mencer,
- Adrian M. Baris,
- Lorinc S. Pongor,
- Mirit I. Aladjem
Affiliations
- Haiqing Fu
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Christophe E. Redon
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Bhushan L. Thakur
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Koichi Utani
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Robin Sebastian
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Sang-Min Jang
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Jacob M. Gross
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Sara Mosavarpour
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Anna B. Marks
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Sophie Z. Zhuang
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Sarah B. Lazar
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Mishal Rao
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Shira T. Mencer
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Adrian M. Baris
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Lorinc S. Pongor
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- Mirit I. Aladjem
- Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-021-23835-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed distribution of replication initiation that over-duplicates early-replicating genomic regions.
