Emerging role of extracellular vesicles in the respiratory system

Abstract

Respiratory system: extracellular vesicles in health and disease Studies of tiny membrane-bound sacs called extracellular vesicles (EVs), which bud from cells naturally but are also implicated in disease, offer insights into respiratory health and disease, and could be used to deliver therapies into respiratory system cells. Joshua Holtzman at Oberlin College, Ohio, USA, and Heedoo Lee at Changwon National University in South Korea review current understanding of the role of EVs in the respiratory system and their potential uses in treatment. Researchers are discovering how EVs deliver signaling molecules to promote respiratory health, and how they can be involved in cancer, autoimmunity, asthma and other diseases. Early trials using EVs to deliver conventional drugs, and small RNA molecules that can control gene activity suggest great potential for treating a range of serious respiratory conditions. Analysis of EVs may also assist in diagnosis.