Nature Communications (Nov 2019)

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

  • Theodore P. Braun,
  • Mariam Okhovat,
  • Cody Coblentz,
  • Sarah A. Carratt,
  • Amy Foley,
  • Zachary Schonrock,
  • Brittany M. Smith,
  • Kimberly Nevonen,
  • Brett Davis,
  • Brianna Garcia,
  • Dorian LaTocha,
  • Benjamin R. Weeder,
  • Michal R. Grzadkowski,
  • Joey C. Estabrook,
  • Hannah G. Manning,
  • Kevin Watanabe-Smith,
  • Sophia Jeng,
  • Jenny L. Smith,
  • Amanda R. Leonti,
  • Rhonda E. Ries,
  • Shannon McWeeney,
  • Cristina Di Genua,
  • Roy Drissen,
  • Claus Nerlov,
  • Soheil Meshinchi,
  • Lucia Carbone,
  • Brian J. Druker,
  • Julia E. Maxson

DOI
https://doi.org/10.1038/s41467-019-13364-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-dependent mechanism.