PLoS ONE (Jan 2014)

Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.

  • Sergio Serrano-Villar,
  • María Jesús Pérez-Elías,
  • Fernando Dronda,
  • José Luis Casado,
  • Ana Moreno,
  • Ana Royuela,
  • José Antonio Pérez-Molina,
  • Talia Sainz,
  • Enrique Navas,
  • José Manuel Hermida,
  • Carmen Quereda,
  • Santiago Moreno

DOI
https://doi.org/10.1371/journal.pone.0085798
Journal volume & issue
Vol. 9, no. 1
p. e85798

Abstract

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BackgroundA low CD4/CD8 ratio has been identified in the general population as a hallmark of inmmunosenescence and a surrogate of all-cause mortality. We aimed to investigate in treated HIV-infected individuals the relationship between the CD4/CD8 ratio and serious non-AIDS events.MethodsCase-control study within a prospective hospital-based cohort of HIV-infected subjects during at least one year of ART-mediated viral suppression. Cases were patients with serious non-AIDS events (non-AIDS malignancies, cardiovascular disease, and end-stage kidney disease), and controls individuals who did not developed non-AIDS events during follow-up. Data were analyzed using ROC analysis and multivariate logistic regression. Conditional logistic regression was performed in 200 cases/controls matched by age, sex, nadir CD4 and proximal CD4 counts.ResultsWe analyzed 407 subjects (109 cases, 298 controls). The CD4/CD8 ratio was lower in cases (0.44 vs. 0.70, PConclusionsThe CD4/CD8 ratio provides additional information to the CD4 counts and nadir CD4 in treated HIV-infected individuals, since it is independently associated with the risk of non-AIDS-related morbidity and mortality. This association is robust and maintained within different subgroups of patients.