Nature Communications (Sep 2018)
Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
- Maurizio Mangolini,
- Frederik Götte,
- Andrew Moore,
- Tim Ammon,
- Madlen Oelsner,
- Gloria Lutzny-Geier,
- Ludger Klein-Hitpass,
- James C. Williamson,
- Paul J. Lehner,
- Jan Dürig,
- Michael Möllmann,
- Lívia Rásó-Barnett,
- Katherine Hughes,
- Antonella Santoro,
- Simón Méndez-Ferrer,
- Robert A. J. Oostendorp,
- Ursula Zimber-Strobl,
- Christian Peschel,
- Daniel J. Hodson,
- Marc Schmidt-Supprian,
- Ingo Ringshausen
Affiliations
- Maurizio Mangolini
- Wellcome Trust/ MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Frederik Götte
- Department of Hematology and Medical Oncology, Klinikum rechts der Isar der Technischen Universität München
- Andrew Moore
- Wellcome Trust/ MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Tim Ammon
- Department of Hematology and Medical Oncology, Klinikum rechts der Isar der Technischen Universität München
- Madlen Oelsner
- Department of Hematology and Medical Oncology, Klinikum rechts der Isar der Technischen Universität München
- Gloria Lutzny-Geier
- Department of Internal Medicine 5, Haematology and Oncology, Friedrich-Alexander-University Erlangen-Nürnberg
- Ludger Klein-Hitpass
- Institute of Cell Biology, Faculty of Medicine, University of Duisburg-Essen
- James C. Williamson
- Cambridge Institute for Medical Research (CIMR), University of Cambridge
- Paul J. Lehner
- Cambridge Institute for Medical Research (CIMR), University of Cambridge
- Jan Dürig
- Department of Hematology, University Hospital Essen,, University of Duisburg-Essen
- Michael Möllmann
- Department of Hematology, University Hospital Essen,, University of Duisburg-Essen
- Lívia Rásó-Barnett
- Haematopathology and Oncology Diagnostic Service (HODS), Cambridge University Hospitals NHS Foundation Trust
- Katherine Hughes
- Department of Veterinary Medicine, University of Cambridge
- Antonella Santoro
- Wellcome Trust/ MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Simón Méndez-Ferrer
- Wellcome Trust/ MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Robert A. J. Oostendorp
- Department of Hematology and Medical Oncology, Klinikum rechts der Isar der Technischen Universität München
- Ursula Zimber-Strobl
- Helmholz Zentrum, Research Unit Gene Vectors
- Christian Peschel
- Department of Hematology and Medical Oncology, Klinikum rechts der Isar der Technischen Universität München
- Daniel J. Hodson
- Wellcome Trust/ MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- Marc Schmidt-Supprian
- Department of Hematology and Medical Oncology, Klinikum rechts der Isar der Technischen Universität München
- Ingo Ringshausen
- Wellcome Trust/ MRC Cambridge Stem Cell Institute & Department of Haematology, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-018-06069-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-survival bidirectional crosstalk between stromal cells and leukemic cells.
