Trichosporon asahii Infection in an Extremely Preterm Infant in China

Abstract

Na Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 3Department of Dermatology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China; 4Department of Pediatrics, Fuyong People’s Hospital, Shenzhen, People’s Republic of China; 5Department of Neonatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Wang, Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email [email protected]: Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated.Keywords: preterm, Trichosporon asahii, fluconazole, voriconazole, China

Keywords

• preterm
• trichosporon asahii
• fluconazole
• voriconazole
• china