Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

A. Rouf Banday; Olusegun O. Onabajo; Seraph Han-Yin Lin; Adeola Obajemu; Joselin M. Vargas; Krista A. Delviks-Frankenberry; Philippe Lamy; Ariunaa Bayanjargal; Clara Zettelmeyer; Oscar Florez-Vargas; Vinay K. Pathak; Lars Dyrskjøt; Ludmila Prokunina-Olsson

doi:10.1038/s42003-021-01844-5

Communications Biology (Mar 2021)

Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

A. Rouf Banday,
Olusegun O. Onabajo,
Seraph Han-Yin Lin,
Adeola Obajemu,
Joselin M. Vargas,
Krista A. Delviks-Frankenberry,
Philippe Lamy,
Ariunaa Bayanjargal,
Clara Zettelmeyer,
Oscar Florez-Vargas,
Vinay K. Pathak,
Lars Dyrskjøt,
Ludmila Prokunina-Olsson

Affiliations

A. Rouf Banday: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Olusegun O. Onabajo: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Seraph Han-Yin Lin: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Adeola Obajemu: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Joselin M. Vargas: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Krista A. Delviks-Frankenberry: Viral Mutation Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
Philippe Lamy: Department of Molecular Medicine, Aarhus University Hospital
Ariunaa Bayanjargal: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Clara Zettelmeyer: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Oscar Florez-Vargas: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Vinay K. Pathak: Viral Mutation Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute
Lars Dyrskjøt: Department of Molecular Medicine, Aarhus University Hospital
Ludmila Prokunina-Olsson: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s42003-021-01844-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 16

Abstract

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A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cancer patients. Expression of this mutagenic isoform could be decreased by inducing skipping of APOBEC3B exon 5 in cells treated with SF3B1 inhibitor or splice-switching oligos.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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