Clinical Ophthalmology (Oct 2023)

Incidence and Risk Factors for Retinopathy of Prematurity in a Tertiary Hospital in China

  • Hu X,
  • Zhang J,
  • Zhang M,
  • Chen X,
  • Han S,
  • Zhu J

Journal volume & issue
Vol. Volume 17
pp. 3189 – 3194

Abstract

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Xiaoshan Hu,* Jun Zhang,* Min Zhang, Xiaohui Chen, Shuping Han, Jingai Zhu Department of Neonatology, Obstetrics and Gynecology Hospital of Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingai Zhu, Department of Neonatology, Obstetrics and Gynecology Hospital of Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210001, People’s Republic of China, Email [email protected]: To investigate the incidence and risk factors for the retinopathy of prematurity (ROP) in the neonatal intensive care unit (NICU) of Obstetrics and Gynecology Hospital of Affiliated to Nanjing Medical University, China.Methods: This retrospective case–control study included 611 preterm infants with birth weight (BW)< 1500 grams admitted to the Department of Neonatology, Obstetrics and Gynecology Hospital of Affiliated to Nanjing Medical University between January 2019 and December 2022. The incidence and risk factors for any stage and severe ROP were analyzed.Results: Within 611 infants, 245(40.1%) developed ROP; 160(26.2%) infants were stage 1, 54(8.8%) were stage 2, and 31(5.1%) were stage 3, no stage 4 and 5. Among them, 22(3.6%) infants needed treatment. Multivariate analysis showed a higher gestational age (GA) was protective, whereas twin birth and moderate-to-severe BPD increased the hazard of any stage ROP; higher BW and male gender were significant risk factors for severe ROP.Conclusion: Compared to other tertiary hospitals, the incidence of any stage ROP in our NICU was higher, but the rate of ROP needed treatment was lower. A higher GA was protective, whereas twin birth and moderate-to-severe BPD increased the hazard of any stage ROP; higher BW was protective, whereas male gender were risk factors for the development of severe ROP.Keywords: retinopathy of prematurity, low birth weight infants, risk factors, incidence

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