Nature Communications (Nov 2021)
Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
- Xue-Ke Zhao,
- Pengwei Xing,
- Xin Song,
- Miao Zhao,
- Linxuan Zhao,
- Yonglong Dang,
- Ling-Ling Lei,
- Rui-Hua Xu,
- Wen-Li Han,
- Pan-Pan Wang,
- Miao-Miao Yang,
- Jing-Feng Hu,
- Kan Zhong,
- Fu-You Zhou,
- Xue-Na Han,
- Chao-Long Meng,
- Jia-Jia Ji,
- Xingqi Chen,
- Li-Dong Wang
Affiliations
- Xue-Ke Zhao
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Pengwei Xing
- Department of Immunology, Genetics and Pathology, Uppsala University
- Xin Song
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Miao Zhao
- Department of Immunology, Genetics and Pathology, Uppsala University
- Linxuan Zhao
- Department of Immunology, Genetics and Pathology, Uppsala University
- Yonglong Dang
- Department of Immunology, Genetics and Pathology, Uppsala University
- Ling-Ling Lei
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Rui-Hua Xu
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Wen-Li Han
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Pan-Pan Wang
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Miao-Miao Yang
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Jing-Feng Hu
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Kan Zhong
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Fu-You Zhou
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Xue-Na Han
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Chao-Long Meng
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Jia-Jia Ji
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- Xingqi Chen
- Department of Immunology, Genetics and Pathology, Uppsala University
- Li-Dong Wang
- State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key, Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University
- DOI
- https://doi.org/10.1038/s41467-021-26745-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dietary habits.
