Nature Communications (Jul 2021)
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
- Nour Ghaddar,
- Shuo Wang,
- Bethany Woodvine,
- Jothilatha Krishnamoorthy,
- Vincent van Hoef,
- Cedric Darini,
- Urszula Kazimierczak,
- Nicolas Ah-son,
- Helmuth Popper,
- Myriam Johnson,
- Leah Officer,
- Ana Teodósio,
- Massimo Broggini,
- Koren K. Mann,
- Maria Hatzoglou,
- Ivan Topisirovic,
- Ola Larsson,
- John Le Quesne,
- Antonis E. Koromilas
Affiliations
- Nour Ghaddar
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Shuo Wang
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Bethany Woodvine
- Leicester Cancer Research Centre, University of Leicester
- Jothilatha Krishnamoorthy
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Vincent van Hoef
- Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute
- Cedric Darini
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Urszula Kazimierczak
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Nicolas Ah-son
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Helmuth Popper
- Diagnostic and Research Institute of Pathology, Medical University of Graz
- Myriam Johnson
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Leah Officer
- MRC Toxicology Unit, University of Cambridge
- Ana Teodósio
- MRC Toxicology Unit, University of Cambridge
- Massimo Broggini
- Laboratory of Molecular Pharmacology IRCCS—Istituto di Ricerche Farmacologiche “Mario Negri”
- Koren K. Mann
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Maria Hatzoglou
- Department of Genetics, Case Western Reserve University
- Ivan Topisirovic
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- Ola Larsson
- Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute
- John Le Quesne
- Leicester Cancer Research Centre, University of Leicester
- Antonis E. Koromilas
- Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital
- DOI
- https://doi.org/10.1038/s41467-021-24661-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting in KRAS-driven lung tumorigenesis.
