Haematologica (Sep 2007)

Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells

  • Cindy Grandjenette,
  • Anne Kennel,
  • Gilbert C. Faure,
  • Marie C. Béné,
  • Pierre Feugier

DOI
https://doi.org/10.3324/haematol.10975
Journal volume & issue
Vol. 92, no. 9

Abstract

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This study reports that B-chronic lymphocytic leukemia (B-CLL) cells display the same pattern of toll-like receptors (TLRs) proteins expression as normal B-cells, yet with overexpression of TLR9. Furthermore, TLR7 and TLR9 appear to be functional and liable to respond to specific ligands, respectively imidazoquinolines and CpG-ODN thus potentially opening new therapeutic approaches.