Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

Guizhi Zhu; Lei Mei; Harshad D. Vishwasrao; Orit Jacobson; Zhantong Wang; Yijing Liu; Bryant C. Yung; Xiao Fu; Albert Jin; Gang Niu; Qin Wang; Fuwu Zhang; Hari Shroff; Xiaoyuan Chen

doi:10.1038/s41467-017-01386-7

Nature Communications (Nov 2017)

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

Guizhi Zhu,
Lei Mei,
Harshad D. Vishwasrao,
Orit Jacobson,
Zhantong Wang,
Yijing Liu,
Bryant C. Yung,
Xiao Fu,
Albert Jin,
Gang Niu,
Qin Wang,
Fuwu Zhang,
Hari Shroff,
Xiaoyuan Chen

Affiliations

Guizhi Zhu: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Lei Mei: Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland
Harshad D. Vishwasrao: Advanced Imaging and Microscopy Resource, NIH
Orit Jacobson: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Zhantong Wang: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Yijing Liu: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Bryant C. Yung: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Xiao Fu: Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, NIH
Albert Jin: Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, NIH
Gang Niu: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Qin Wang: Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland
Fuwu Zhang: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Hari Shroff: Advanced Imaging and Microscopy Resource, NIH
Xiaoyuan Chen: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)

DOI: https://doi.org/10.1038/s41467-017-01386-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short hairpin RNA and tumor-specific peptide neoantigens.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal