Nature Communications (Mar 2019)
The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
- Hannah C. Slater,
- Amanda Ross,
- Ingrid Felger,
- Natalie E. Hofmann,
- Leanne Robinson,
- Jackie Cook,
- Bronner P. Gonçalves,
- Anders Björkman,
- Andre Lin Ouedraogo,
- Ulrika Morris,
- Mwinyi Msellem,
- Cristian Koepfli,
- Ivo Mueller,
- Fitsum Tadesse,
- Endalamaw Gadisa,
- Smita Das,
- Gonzalo Domingo,
- Melissa Kapulu,
- Janet Midega,
- Seth Owusu-Agyei,
- Cécile Nabet,
- Renaud Piarroux,
- Ogobara Doumbo,
- Safiatou Niare Doumbo,
- Kwadwo Koram,
- Naomi Lucchi,
- Venkatachalam Udhayakumar,
- Jacklin Mosha,
- Alfred Tiono,
- Daniel Chandramohan,
- Roly Gosling,
- Felista Mwingira,
- Robert Sauerwein,
- Richard Paul,
- Eleanor M Riley,
- Nicholas J White,
- Francois Nosten,
- Mallika Imwong,
- Teun Bousema,
- Chris Drakeley,
- Lucy C Okell
Affiliations
- Hannah C. Slater
- MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- Amanda Ross
- Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute
- Ingrid Felger
- University of Basel
- Natalie E. Hofmann
- University of Basel
- Leanne Robinson
- Vector-borne Diseases Unit, Papua New Guinea Institute for Medical Research
- Jackie Cook
- MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine
- Bronner P. Gonçalves
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Anders Björkman
- Malaria Research, Department of Microbiology, Tumor and Cell Biology
- Andre Lin Ouedraogo
- Département de Sciences Biomédicales, Centre National de Recherche et de Formation sur le Paludisme
- Ulrika Morris
- Malaria Research, Department of Microbiology, Tumor and Cell Biology
- Mwinyi Msellem
- Department of Training and Research, Mnazi Mmoja Hospital
- Cristian Koepfli
- Population Health and Immunity Division, Walter and Eliza Hall Institute
- Ivo Mueller
- Division of Population Health and Immunity, The Walter and Eliza Hall Institute of Medical Research
- Fitsum Tadesse
- Radboud Institute for Health Sciences, Radboud University Medical Centre
- Endalamaw Gadisa
- Armauer Hansen Research Institute
- Smita Das
- Diagnostics Program, PATH, Seattle
- Gonzalo Domingo
- Diagnostics Program, PATH, Seattle
- Melissa Kapulu
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Janet Midega
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Seth Owusu-Agyei
- Institute of Health, University of Health and Allied Sciences
- Cécile Nabet
- Sorbonne Université, INSERM, Institut Pierre-Louis d’Epidémiologie et de Santé Publique, AP- HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie-Mycologie
- Renaud Piarroux
- Sorbonne Université, INSERM, Institut Pierre-Louis d’Epidémiologie et de Santé Publique, AP- HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie-Mycologie
- Ogobara Doumbo
- Malaria Research and Training Centre, Parasitic Diseases Epidemiology Department, UMI 3189, University of Sciences, Technique and Technology
- Safiatou Niare Doumbo
- Malaria Research and Training Centre, Parasitic Diseases Epidemiology Department, UMI 3189, University of Sciences, Technique and Technology
- Kwadwo Koram
- Noguchi Memorial Institute for Medical Research, University of Ghana
- Naomi Lucchi
- Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention
- Venkatachalam Udhayakumar
- Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention
- Jacklin Mosha
- National Institute for Medical Research, Mwanza Medical Research Centre
- Alfred Tiono
- Department of Biomedical Sciences, Centre National de Recherche et de Formation sur le Paludisme
- Daniel Chandramohan
- Department of Disease Control, London School of Hygiene and Tropical Medicine
- Roly Gosling
- Malaria Elimination Initiative, Global Health Group, University of California, San Francisco
- Felista Mwingira
- Biological Sciences Department, Dar es Salaam University College of Education
- Robert Sauerwein
- Radboud Institute for Health Sciences, Radboud University Medical Centre
- Richard Paul
- Institut Pasteur de Dakar, Laboratoire d‘Entomologie Médicale
- Eleanor M Riley
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Nicholas J White
- Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford
- Francois Nosten
- Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford
- Mallika Imwong
- Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Teun Bousema
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Chris Drakeley
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Lucy C Okell
- MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-019-09441-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The role of subpatent infections for malaria transmission and elimination is unclear. Here, Slater et al. analyse several malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections.
