Dihydroartemisinin imposes positive and negative regulation on Treg and plasma cells via direct interaction and activation of c-Fos

Qilong Li; Ning Jiang; Yiwei Zhang; Yize Liu; Ziwei Su; Quan Yuan; Xiaoyu Sang; Ran Chen; Ying Feng; Qijun Chen

doi:10.1038/s42003-023-04454-5

Communications Biology (Jan 2023)

Dihydroartemisinin imposes positive and negative regulation on Treg and plasma cells via direct interaction and activation of c-Fos

Qilong Li,
Ning Jiang,
Yiwei Zhang,
Yize Liu,
Ziwei Su,
Quan Yuan,
Xiaoyu Sang,
Ran Chen,
Ying Feng,
Qijun Chen

Affiliations

Qilong Li: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Ning Jiang: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Yiwei Zhang: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Yize Liu: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Ziwei Su: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Quan Yuan: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Xiaoyu Sang: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Ran Chen: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Ying Feng: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University
Qijun Chen: Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University

DOI: https://doi.org/10.1038/s42003-023-04454-5
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 14

Abstract

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Dihydroartemisinin (DHA) promotes Treg cell proliferation and suppresses plasma cell expansion through direct interaction and activation of c-Fos, underling the bilateral immunoregulatory mechanism of DHA.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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