Stem Cell Research & Therapy (Jul 2024)

Applications of extraembryonic tissue-derived cells in vascular tissue regeneration

  • Mehdi Amiri Goushki,
  • Zahra Kharat,
  • Mousa Kehtari,
  • Alireza Naderi Sohi,
  • Hana Hanaee Ahvaz,
  • Iman Rad,
  • Simzar HosseinZadeh,
  • Fatemeh Kouhkan,
  • Mahboubeh Kabiri

DOI
https://doi.org/10.1186/s13287-024-03784-3
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 18

Abstract

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Abstract Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and developing new therapeutic approaches for heart disease treatment. To date, different sources of cells have been recognized that offer assistance within the recovery of heart supply routes and veins with distinctive capacities and are compelling for heart regeneration. However, some challenges still remain that need to be overcome to establish the full potential application of these cells. In this paper, we review the different cell sources used for vascular tissue engineering, focusing on extraembryonic tissue-derived cells (ESCs), and elucidate their roles in cardiovascular disease. In addition, we highlight the intricate interplay between mechanical and biochemical factors in regulating mesenchymal stem cell (MSC) differentiation, offering insights into optimizing their application in vascular tissues.

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