New Microbes and New Infections (Sep 2021)
The forgotten oral microbial transplantation for improving the outcomes of COVID-19
- A. AbdelMassih,
- M. Gadalla,
- E. Hussein,
- M. Elahmady,
- N. Zahra,
- M.A. Eid,
- M. Hussein,
- A.A. Hassan,
- A.S. Abou-Zeid,
- A. Hassan,
- N. El Nahhas,
- N. Emad,
- N. Aboushadi,
- N. Ibrahim,
- S. Mokhtar,
- N. El-Husseiny,
- A. Kamel,
- R. Hozaien,
- E. Menshawey,
- H.A. Ismail,
- M. Mokhles,
- R. Menshawey,
- R. Fouda
Affiliations
- A. AbdelMassih
- Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, Egypt; Pediatric Cardio-Oncology Department, Children Cancer Hospital of Egypt (57357), Egypt; Corresponding author: A. AbdelMassih, Pediatric Department, Pediatric Cardiology Unit, Cairo University Children Hospital, Faculty of Medicine, Cairo University, Kasr Al Ainy Street, Cairo, 12411, Egypt
- M. Gadalla
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- E. Hussein
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- M. Elahmady
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- N. Zahra
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- M.A. Eid
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- M. Hussein
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- A.A. Hassan
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- A.S. Abou-Zeid
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- A. Hassan
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- N. El Nahhas
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- N. Emad
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- N. Aboushadi
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- N. Ibrahim
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- S. Mokhtar
- Faculty of Dentistry, New Giza University, New Giza, Egypt; Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- N. El-Husseiny
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt; Faculty of Dentistry, Cairo University, Egypt; Pixagon Graphic Design Agency, Cairo, Egypt
- A. Kamel
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- R. Hozaien
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- E. Menshawey
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- H.A. Ismail
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- M. Mokhles
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- R. Menshawey
- Research Accessibility Team (Students' and Interns' Research Program), Faculty of Medicine, Cairo University, Egypt
- R. Fouda
- Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt
- Journal volume & issue
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Vol. 43
p. 100923
Abstract
Ever since the uncovering of the severe discrepancy of COVID-19 manifestations, irrespective of viral load, scientists have raced to locate and manage factors contributing to the genesis of a critical state. Recent evidence delineates the role of oral dysbiosis in the development of low-grade inflammation, characterized by the increase of inflammatory cytokines common to those fundamental to the development of severe COVID. Furthermore, high periodontopathic bacteria were recorded in severe acute respiratory syndrome in COVID patients, as well as its common provoking comorbidities such as diabetes and hypertension. This can be explained by the immigration and elimination of oral bacteria into the airways, which, in the context of an injured lung, allows for their preferential overgrowth familiar to that, causing the progression to advanced lung diseases. This is why we indicate the promising usage of oral microbiome transplantation as a treatment of oral microbial dysbiosis, not only associated with the worst outcomes of COVID-19 but also in other disorders of low-grade inflammation.
